Article
Functional exploration of the adult ovarian granulosa cell tumor-associated somatic FOXL2 mutation p.Cys134Trp (c.402C>G).
PloS one - 20 Jan 2010
Benayoun Bérénice A, Caburet Sandrine, Dipietromaria Aurélie, Georges Adrien, D'Haene Barbara, Pandaranayaka P J Eswari, L'Hôte David, Todeschini Anne-Laure, Krishnaswamy Sankaran, Fellous Marc, De Baere Elfride, Veitia Reiner A
Abstract excerpt
BACKGROUND: The somatic mutation in the FOXL2 gene c.402C>G (p.Cys134Trp) has recently been identified in the vast majority of adult ovarian granulosa cell tumors (OGCTs) studied. In addition, this mutation seems to be specific to adult OGCTs and is likely to be a driver of malignant transformation. However, its pathogenic mechanisms remain elusive. METHODOLOGY/PRINCIPAL FINDINGS: We have sequenced the FOXL2 open...
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