Article
Expression of pituitary tumour-derived, N-terminally truncated isoform of fibroblast growth factor receptor 4 (ptd-FGFR4) correlates with tumour invasiveness but not with G-protein alpha subunit (gsp) mutation in human GH-secreting pituitary adenomas.
Clinical endocrinology - 1 Mar 2008
Morita Koji, Takano Koji, Yasufuku-Takano Junko, Yamada Shozo, Teramoto Akira, Takei Mao, Osamura Robert Yoshiyuki, Sano Toshiaki, Fujita Toshiro
Abstract excerpt
OBJECTIVE: Apart from the constitutively activating mutation of the G-protein alpha subunit (Gsalpha) (gsp mutation), factors involved in tumorigenesis or those in tumour behaviour remain elusive in sporadic GH-secreting pituitary adenomas. Recently, the N-terminally truncated form of fibroblast growth factor receptor-4 (ptd-FGFR4) was identified in pituitary adenomas. This aberrant receptor has transforming...
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