Genetic aspects of pituitary tumors.

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Article

Genetic aspects of pituitary tumors.

Journal of pediatric endocrinology & metabolism : JPEM - 1 Jan 2001

Spada A

Abstract excerpt

Pituitary adenomas arise from the replication of a single mutated cell in which growth advantage may result from either activation of protooncogenes or inactivation of antioncogenes. The search for oncogenes in the genesis of these tumors has yielded negative results except for the gsp oncogene, that has been identified in about 30-40% of GH-secreting adenomas. gsp mutations cause constitutive activation of the...

Topics

Animals
Gene Expression Regulation, Neoplastic
Humans
Mutation
Oncogenes
Pituitary Neoplasms

Source

Open in PubMed

Identifiers

PMID: 11964015

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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