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Article

Absence of constitutively activating mutations in the GHRH receptor in GH-producing pituitary tumors.

The Journal of clinical endocrinology and metabolism - 1 Aug 2001

Lee E J, Kotlar T J, Ciric I, Lee M K, Lim S K, Lee H C, Huh K B, Mayo K E, Jameson J L

Abstract excerpt

The molecular events leading to the development of GH-producing pituitary tumors remain largely unknown. We hypothesized that activating mutations of the GHRH receptor might occur in a subset of GH-producing pituitary tumors. Genomic DNA samples from 54 GH-producing pituitary tumor tissues were screened for mutations of the GHRH receptor. Eleven homozygous or heterozygous nucleotide substitutions [169G > A...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 11502843
DOI: 10.1210/jcem.86.8.7732

Genes

GHRH

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Absence of constitutively activating mutations in the GHRH receptor in GH-producing pituitary tumors.PMID 11502843Read ↗

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