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Article

Pak1 and PIX regulate contact inhibition during epithelial wound healing.

The EMBO journal - 15 Aug 2003

Zegers Mirjam M P, Forget Marie-Annick, Chernoff Jonathan, Mostov Keith E, ter Beest Martin B A, Hansen Steen H

Abstract excerpt

Wound healing in epithelia requires coordinated cell migration and proliferation regulated by signaling mechanisms that are poorly understood. Here we show that epithelial cells expressing constitutively active or kinase-dead mutants of the Rac/Cdc42 effector Pak1 fail to undergo growth arrest upon wound closure. Strikingly, this phenotype is only observed when the Pak1 kinase mutants are expressed in cells...

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Identifiers

PMID: 12912914
DOI: 10.1093/emboj/cdg398
PMCID: PMC175788

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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