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Article

PAK1 phosphorylation of MEK1 regulates fibronectin-stimulated MAPK activation.

The Journal of cell biology - 21 Jul 2003

Slack-Davis Jill K, Eblen Scott T, Zecevic Maja, Boerner Scott A, Tarcsafalvi Adel, Diaz H Bruce, Marshall Mark S, Weber Michael J, Parsons J Thomas, Catling Andrew D

Abstract excerpt

Activation of the Ras-MAPK signal transduction pathway is necessary for biological responses both to growth factors and ECM. Here, we provide evidence that phosphorylation of S298 of MAPK kinase 1 (MEK1) by p21-activated kinase (PAK) is a site of convergence for integrin and growth factor signaling. We find that adhesion to fibronectin induces PAK1-dependent phosphorylation of MEK1 on S298 and that this...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 12876277
DOI: 10.1083/jcb.200212141
PMCID: PMC2172784

Genes

PAK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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