Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Filamin is essential in actin cytoskeletal assembly mediated by p21-activated kinase 1.

Nature cell biology - 1 Sept 2002

Vadlamudi Ratna K, Li Feng, Adam Liana, Nguyen Diep, Ohta Yasutaka, Stossel Thomas P, Kumar Rakesh

Abstract excerpt

The serine/threonine kinase p21-activated kinase 1 (Pak1) controls the actin cytoskeletal and ruffle formation through mechanisms that are independent of GTPase activity. Here we identify filamin FLNa as a Pak1-interacting protein through a yeast two-hybrid screen using the amino terminus of Pak1 as a bait. FLNa is stimulated by physiological signalling molecules to undergo phosphorylation by Pak1 and to interact...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Contractile Proteins
Share to Cytoskeleton

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Filamins

Share to Lim Kinases

Share to Luminescent Proteins

Share to Mitogen-Activated Protein Kinases

Share to p21-Activated Kinases

Share to Two-Hybrid System Techniques

Source

Identifiers

PMID: 12198493
DOI: 10.1038/ncb838

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Filamin is essential in actin cytoskeletal assembly mediated by p21-activated kinase 1.PMID 12198493Read ↗

Deficiency of filamin A in smooth muscle cells protects against hypoxia‑mediated pulmonary hypertension in miceSemantic proximity Read ↗

The function and pathogenic mechanism of filamin A.Semantic proximity Read ↗

p41-Arc subunit of human Arp2/3 complex is a p21-activated kinase-1-interacting substrate.Semantic proximity Read ↗

p21-Activated Kinase 1 Plays a Critical Role in Cellular Activation by NefSemantic proximity Read ↗

FilGAP, a Rho- and ROCK-regulated GAP for Rac binds filamin A to control actin remodelling.Semantic proximity Read ↗

The p21-activated kinases in neural cytoskeletal remodeling and related neurological disordersSemantic proximity Read ↗

The filamins: organizers of cell structure and function.Semantic proximity Read ↗

FLNa negatively regulated proliferation and metastasis in lung adenocarcinoma A549 cells via suppression of EGFRSemantic proximity Read ↗

Nuclear Localization and Chromatin Targets of p21-activated Kinase 1Semantic proximity Read ↗

Localization of p21-activated kinase 1 (PAK1) to pinocytic vesicles and cortical actin structures in stimulated cells.Semantic proximity Read ↗

Expression of constitutively active alpha-PAK reveals effects of the kinase on actin and focal complexes.Semantic proximity Read ↗

PAK signaling in cancerSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.