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Article

Regulation of microfilament reorganization and invasiveness of breast cancer cells by kinase dead p21-activated kinase-1.

The Journal of biological chemistry - 21 Apr 2000

Adam L, Vadlamudi R, Mandal M, Chernoff J, Kumar R

Abstract excerpt

Stimulation of growth factor signaling has been implicated in the development of invasive phenotype and p21-activated kinase (PAK1) activation in human breast epithelial cancer cells. To further explore the roles of PAK1 in the invasive behavior of breast cancer cells, in the present study we investigated the influence of inhibition of PAK1 activity on the reorganization of cytoskeleton components that control...

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Source

Identifiers

PMID: 10766836
DOI: 10.1074/jbc.275.16.12041

Genes

PAK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Regulation of microfilament reorganization and invasiveness of breast cancer cells by kinase dead p21-activated kinase-1.PMID 10766836Read ↗

PAK-dependent regulation of actin dynamics in breast cancer cellsSemantic proximity Read ↗

Regulatable expression of p21-activated kinase-1 promotes anchorage-independent growth and abnormal organization of mitotic spindles in human epithelial breast cancer cells.Semantic proximity Read ↗

Molecular Pathways: Targeting P21-Activated Kinase 1 Signaling in Cancer—Opportunities, Challenges, and LimitationsSemantic proximity Read ↗

Heregulin regulates cytoskeletal reorganization and cell migration through the p21-activated kinase-1 via phosphatidylinositol-3 kinase.Semantic proximity Read ↗

Expression of constitutively active alpha-PAK reveals effects of the kinase on actin and focal complexes.Semantic proximity Read ↗

Pak1 regulates focal adhesion strength, myosin IIA distribution, and actin dynamics to optimize cell migration.Semantic proximity Read ↗

PAK1 regulates myosin II-B phosphorylation, filament assembly, localization and cell chemotaxis.Semantic proximity Read ↗

Constitutive p21-activated kinase (PAK) activation in breast cancer cells as a result of mislocalization of PAK to focal adhesions.Semantic proximity Read ↗

Pak1 Kinase Links ErbB2 to β-Catenin in Transformation of Breast Epithelial CellsSemantic proximity Read ↗

PAK1 phosphorylation of MEK1 regulates fibronectin-stimulated MAPK activation.Semantic proximity Read ↗

Filamin B Enhances the Invasiveness of Cancer Cells into 3D Collagen MatricesSemantic proximity Read ↗

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