Article
Diminished inflammation and nociceptive pain with preservation of neuropathic pain in mice with a targeted mutation of the type I regulatory subunit of cAMP-dependent protein kinase.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 1 Oct 1997
Malmberg A B, Brandon E P, Idzerda R L, Liu H, McKnight G S, Basbaum A I
Abstract excerpt
To assess the contribution of PKA to injury-induced inflammation and pain, we evaluated nociceptive responses in mice that carry a null mutation in the gene that encodes the neuronal-specific isoform of the type I regulatory subunit (RIbeta) of PKA. Acute pain indices did not differ in the RIbeta PKA mutant mice compared with wild-type controls. However, tissue injury-evoked persistent pain behavior, inflammation...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.