Article
A novel nociceptor signaling pathway revealed in protein kinase C epsilon mutant mice.
Neuron - 1 Sept 1999
Khasar S G, Lin Y H, Martin A, Dadgar J, McMahon T, Wang D, Hundle B, Aley K O, Isenberg W, McCarter G, Green P G, Hodge C W, Levine J D, Messing R O
Abstract excerpt
There is great interest in discovering new targets for pain therapy since current methods of analgesia are often only partially successful. Although protein kinase C (PKC) enhances nociceptor function, it is not known which PKC isozymes contribute. Here, we show that epinephrine-induced mechanical and thermal hyperalgesia and acetic acid-associated hyperalgesia are markedly attenuated in PKCepsilon mutant mice,...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.