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Article

Normal sensitivity to acute pain, but increased inflammatory hyperalgesia in mice lacking the nociceptin precursor polypeptide or the nociceptin receptor.

The European journal of neuroscience - 1 Jun 2003

Depner Ulrike B, Reinscheid Rainer K, Takeshima Hiroshi, Brune Kay, Zeilhofer Hanns Ulrich

Abstract excerpt

Nociceptin/orphanin FQ (N/OFQ) is the endogenous agonist of the N/OFQ peptide receptor (NOP receptor). It is released from a larger precursor polypeptide, called prepro-nociceptin (ppN/OFQ) from which, in addition to N/OFQ, other biologically active neuropeptides may be derived. Increasing evidence indicates that exogenous application of N/OFQ to the central nervous system of mice and rats induces pro- and...

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Source

Identifiers

PMID: 12814369
DOI: 10.1046/j.1460-9568.2003.02676.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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