Article
Contribution of the tetrodotoxin-resistant voltage-gated sodium channel NaV1.9 to sensory transmission and nociceptive behavior.
Proceedings of the National Academy of Sciences of the United States of America - 28 Jun 2005
Priest Birgit T, Murphy Beth A, Lindia Jill A, Diaz Carmen, Abbadie Catherine, Ritter Amy M, Liberator Paul, Iyer Leslie M, Kash Shera F, Kohler Martin G, Kaczorowski Gregory J, MacIntyre D Euan, Martin William J
Abstract excerpt
The transmission of pain signals after injury or inflammation depends in part on increased excitability of primary sensory neurons. Nociceptive neurons express multiple subtypes of voltage-gated sodium channels (NaV1s), each of which possesses unique features that may influence primary afferent e...
Topics
- Anesthetics, Local
- Animals
- Behavior, Animal
- DNA Primers
- DNA, Complementary
- Electrophysiology
- Female
- Ganglia, Spinal
- Gene Expression Regulation
- Hyperalgesia
- Inflammation
- Male
- Mice