The effect of different TP53 mutations on the chromosomal stability of a human colonic adenoma derived cell line with endogenous wild type TP53 activity, before and after DNA damage.

doi:10.1002/(sici)1098-2264(199709)20:1<44::aid-gcc7>3.0.co;2-9

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

The effect of different TP53 mutations on the chromosomal stability of a human colonic adenoma derived cell line with endogenous wild type TP53 activity, before and after DNA damage.

Genes, chromosomes & cancer - 1 Sept 1997

Williams A C, Miller J C, Collard T, Browne S J, Newbold R F, Paraskeva C

Abstract excerpt

We examined the effect of loss of wild type TP53 activity on the chromosomal stability of a human colonic adenoma derived cell line (designated AA/Cl) by studying transfected variants which express different TP53 mutations. Using gross chromosomal aberrations as a measure of instability, we studi...

Topics

Adenoma
Carcinogenicity Tests
Cell Survival
Chromosomes
Colonic Neoplasms
DNA Damage
Genes, p53
Humans
Mutation
Radiation Dosage
Telomerase
Tumor Cells, Cultured
Tumor Stem Cell Assay

Source

Open in PubMed

Identifiers

PMID: 9290953
DOI: 10.1002/(sici)1098-2264(199709)20:1<44::aid-gcc7>3.0.co;2-9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9290953-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics