Article
Transactivational and DNA binding abilities of endogenous p53 in p53 mutant cell lines.
Oncogene - 1 Jul 1994
Park D J, Nakamura H, Chumakov A M, Said J W, Miller C W, Chen D L, Koeffler H P
Abstract excerpt
Cells with divergent mutant alleles of the p53 gene have different biological and biochemical properties in vitro. Increasing evidence indicates that p53 is a transcriptional activator, and recently, high affinity DNA binding sites for p53 have been identified. The purpose of this study was to determine in vivo, the effect that various mutant p53 proteins have on their ability to mediate transactivation and to...
Topics
- Base Sequence
- Binding Sites
- DNA
- Genes, p53
- Heterozygote
- Homozygote
- Humans
- Molecular Sequence Data
- Mutation
- Protein Binding
- Transcriptional Activation
- Tumor Cells, Cultured