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Article

Differential effects of novel tumour-derived p53 mutations on the transformation of NIH-3T3 cells.

Biological chemistry - 1 Jan 2008

Donninger Howard, Binder Anke, Bohm Lothar, Parker M Iqbal

Abstract excerpt

The p53 tumour suppressor gene is frequently mutated in human tumours and different tumour-derived mutations have varying effects on cells. The effect of a novel tumour-derived p53 mutation and two recently described mutations from South African breast cancer patients on the growth rate, colony formation, cell cycle arrest after irradiation and response to chemotherapeutic drugs was investigated. None of the p53...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 18095870
DOI: 10.1515/BC.2008.010

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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