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Article

Methylation of<i>CASP8, DCR2</i>, and<i>HIN-1</i>in Neuroblastoma Is Associated with Poor Outcome

1 Jun 2007

Abstract excerpt

PURPOSE: Epigenetic aberrations have been shown to play an important role in the pathogenesis of most cancers. To investigate the clinical significance of epigenetic changes in neuroblastoma, we evaluated the relationship between clinicopathologic variables and the pattern of gene methylation in neuroblastoma cell lines and tumors. EXPERIMENTAL DESIGN: Methylation-specific PCR was used to evaluate the gene...

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PMID: 17545522
DOI: 10.1158/1078-0432.ccr-06-2846

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