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Article

Cerebellar gamma-aminobutyric acid type A receptors: pharmacological subtypes revealed by mutant mouse lines.

Molecular pharmacology - 1 Sept 1997

Mäkelä R, Uusi-Oukari M, Homanics G E, Quinlan J J, Firestone L L, Wisden W, Korpi E R

Abstract excerpt

The vast molecular heterogeneity of brain gamma-aminobutyric acid type A (GABAA) receptors forms the basis for receptor subtyping. Using autoradiographic techniques, we established the characteristics of cerebellar granule cell GABAA receptors by comparing wild-type mice with those with a targeted disruption of the alpha6 subunit gene. Cerebellar granule cells of alpha6(-/-) animals have severe deficits in high...

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PMID: 9281599
DOI: 10.1124/mol.52.3.380

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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