Article
Natural mutation of GABAA receptor alpha 6 subunit alters benzodiazepine affinity but not allosteric GABA effects.
European journal of pharmacology - 15 Sept 1993
Korpi E R, Seeburg P H
Abstract excerpt
The binding of the imidazobenzodiazepine, [3H]Ro 15-4513, to cerebellar granule cell-specific GABAA/benzodiazepine receptors is typically insensitive to benzodiazepine receptor agonists such as diazepam. A mutation in the alpha 6 subunit, causing replacement of the arginine at the 100 position by...
Topics
- Animals
- Azides
- Benzodiazepines
- Binding Sites
- Bridged Bicyclo Compounds
- Bridged Bicyclo Compounds, Heterocyclic
- Cell Line
- Cerebellum
- Cloning, Molecular
- Convulsants
- Diazepam
- Granulocytes
- Humans
- Kidney
- Muscimol
- Mutation
- Picrotoxin
- Rats