Somato-synaptic variation of GABA(A) receptors in cultured murine cerebellar granule cells: investigation of the role of the alpha6 subunit.

doi:10.1016/s0028-3908(00)00007-1

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Article

Somato-synaptic variation of GABA(A) receptors in cultured murine cerebellar granule cells: investigation of the role of the alpha6 subunit.

Neuropharmacology - 10 Jul 2000

Mellor J R, Wisden W, Randall A D

Abstract excerpt

Electrophysiological investigation of cultured cerebellar murine granule cells revealed differences between the GABA(A) receptors at inhibitory synapses and those on the cell body. Specifically, mIPSCs decayed more rapidly than cell body receptors deactivated, the mean single channel conductance at the synapse (32 pS) was greater than that at cell body (21 pS) and only cell body receptors were sensitive to Zn(2+)...

Topics

Animals
Benzodiazepines
Cells, Cultured
Cerebellum
Electric Stimulation
Ethylenediamines
Kinetics
Membrane Potentials
Mice
Mice, Inbred C57BL
Mice, Inbred Strains
Mutation
Receptors, GABA-A
Synapses
Time Factors
Zinc
gamma-Aminobutyric Acid

Source

Open in PubMed

Identifiers

PMID: 10854895
DOI: 10.1016/s0028-3908(00)00007-1

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