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Article

Altered receptor subtypes in the forebrain of GABA(A) receptor delta subunit-deficient mice: recruitment of gamma 2 subunits.

Neuroscience - 1 Jan 2002

Korpi E R, Mihalek R M, Sinkkonen S T, Hauer B, Hevers W, Homanics G E, Sieghart W, Lüddens H

Abstract excerpt

A GABA(A) receptor delta subunit-deficient mouse line was created by homologous recombination in embryonic stem cells to investigate the role of the subunit in the brain GABA(A) receptors. High-affinity [(3)H]muscimol binding to GABA sites as studied by ligand autoradiography was reduced in various brain regions of delta(-/-) animals. [(3)H]Ro 15-4513 binding to benzodiazepine sites was increased in delta(-/-)...

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PMID: 11927155
DOI: 10.1016/s0306-4522(01)00527-9

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