Article
Phenotypic and genotypic analysis of rats with cerebellar GABAA receptors composed from mutant and wild-type alpha 6 subunits.
Journal of neurochemistry - 1 Dec 1995
Mäkelä R, Wong G, Lüddens H, Korpi E R
Abstract excerpt
The alcohol-sensitive (ANT) rat line, developed for high behavioral sensitivity to ethanol, also exhibits enhanced sensitivity to benzodiazepines, such as diazepam. The rat line carries a point mutation in the cerebellum-specific gamma-aminobutyric acid type A (GABAA) receptor subunit alpha 6, making their diazepam-insensitive (DIS) receptors sensitive to diazepam. We now report that phenotypes of individual ANT...
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