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Article

Phenotypic and genotypic analysis of rats with cerebellar GABAA receptors composed from mutant and wild-type alpha 6 subunits.

Journal of neurochemistry - 1 Dec 1995

Mäkelä R, Wong G, Lüddens H, Korpi E R

Abstract excerpt

The alcohol-sensitive (ANT) rat line, developed for high behavioral sensitivity to ethanol, also exhibits enhanced sensitivity to benzodiazepines, such as diazepam. The rat line carries a point mutation in the cerebellum-specific gamma-aminobutyric acid type A (GABAA) receptor subunit alpha 6, making their diazepam-insensitive (DIS) receptors sensitive to diazepam. We now report that phenotypes of individual ANT...

Topics

Animals
Azides
Base Sequence
Benzodiazepines
Cerebellum
Diazepam
Genotype
Heterozygote
Molecular Probes
Molecular Sequence Data
Mutation
Phenotype

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Rats

Receptors, GABA-A

Recombinant Proteins

Source

Identifiers

PMID: 7595533
DOI: 10.1046/j.1471-4159.1995.65062401.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7595533-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Phenotypic and genotypic analysis of rats with cerebellar GABAA receptors composed from mutant and wild-type alpha 6 subunits.PMID 7595533Read ↗

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