Article
Targeted disruption of the GABA(A) receptor delta subunit gene leads to an up-regulation of gamma 2 subunit-containing receptors in cerebellar granule cells.
The Journal of biological chemistry - 30 Mar 2001
Tretter V, Hauer B, Nusser Z, Mihalek R M, Höger H, Homanics G E, Somogyi P, Sieghart W
Abstract excerpt
GABA(A) receptors are chloride channels composed of five subunits. Cerebellar granule cells express abundantly six subunits belonging to four subunit classes. These are assembled into a number of distinct receptors, but the regulation of their relative proportions is yet unknown. Here, we studied the composition of cerebellar GABA(A) receptors after targeted disruption of the delta subunit gene. In membranes and...
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