Article
The glutamine 27 beta2-adrenoceptor polymorphism is associated with elevated IgE levels in asthmatic families.
The Journal of allergy and clinical immunology - 1 Aug 1997
Dewar J C, Wilkinson J, Wheatley A, Thomas N S, Doull I, Morton N, Lio P, Harvey J F, Liggett S B, Holgate S T, Hall I P
Abstract excerpt
BACKGROUND: The beta2-adrenoceptor polymorphisms occurring at amino acid positions 16 (arginine to glycine) and 27 (glutamine to glutamate) are known to be functionally relevant and also disease-modifying in subjects with asthma. However, the contribution of these polymorphisms to the development of the asthmatic phenotype or other markers for allergic disease remains to be established. OBJECTIVE: This large...
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