Article
Resistance to monoclonal antibody-induced CD8+ T-cell depletion in thymectomized MHC class II-deficient mice.
Transplantation - 15 Aug 1997
Zhao Y, Sykes M
Abstract excerpt
BACKGROUND: CD8+ T cells are present at higher than normal levels in MHC class II-deficient (IIKO) mice. METHODS: In this study, we have examined the sensitivity of CD8+ T cells to depletion induced by a single injection or multiple injections of an anti-CD8 monoclonal antibody (mAb) (2.43) in II...
Topics
- Animals
- Antibodies, Monoclonal
- CD8 Antigens
- CD8-Positive T-Lymphocytes
- Drug Resistance
- Immunologic Memory
- Lymphocyte Depletion
- Mice
- Mice, Inbred C57BL
- Mice, Knockout
- Phenotype
- Thymectomy