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Article

Aging leads to disturbed homeostasis of memory phenotype CD8(+) cells.

The Journal of experimental medicine - 4 Feb 2002

Zhang Xiaohong, Fujii Hideki, Kishimoto Hidehiro, LeRoy Eric, Surh Charles D, Sprent Jonathan

Abstract excerpt

Examining the rate of in vivo T cell turnover (proliferation) in aged mice revealed a marked reduction in turnover at the level of memory-phenotype CD44(hi) CD8(+) cells relative to young mice. Based on adoptive transfer experiments, the reduced turnover of aged CD44(hi) CD8(+) cells reflected an inhibitory influence of the aged host environment. Aged CD44(hi) CD8(+) cells also showed poor in vivo responses to...

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Identifiers

PMID: 11828003
DOI: 10.1084/jem.20011267
PMCID: PMC2193587

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Source receipt: pubmed, retrieved 7 Sept 2026.

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