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Article

Effects of in vivo T lymphocyte subset depletion on mycobacterial infections in mice.

Journal of leukocyte biology - 1 Mar 1992

Flory C M, Hubbard R D, Collins F M

Abstract excerpt

The relative importance of CD4+ and CD8+ T cell subsets in the expression of acquired resistance to systemic infection by Mycobacterium kansasii was determined. T cell subsets were depleted in thymectomized C57BL/6 mice by the intravenous administration of monoclonal antibodies directed against the relevant T cell determinants. Depletion of the CD4+ subset exacerbated the severity of the infection in...

Topics

Animals
CD4-Positive T-Lymphocytes
CD8 Antigens
Lymphocyte Depletion
Male
Mice
Mice, Inbred C57BL
Mice, Inbred DBA
Mycobacterium Infections
Mycobacterium Infections, Nontuberculous
Phenotype

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

T-Lymphocyte Subsets

Source

Identifiers

PMID: 1347311
DOI: 10.1002/jlb.51.3.225

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1347311-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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