Article
The interactions of APC, E-cadherin and beta-catenin in tumour development and progression.
The Journal of pathology - 1 Jun 1997
Ilyas M, Tomlinson I P
Abstract excerpt
Much progress has been made in identifying genes mutated during the development of colorectal carcinoma. Mutation of the APC gene in particular appears to be fundamental for colorectal tumour initiation. In contrast, loss of expression of E-cadherin appears to be a late event, which may be import...
Topics
- Cadherins
- Colorectal Neoplasms
- Cytoskeletal Proteins
- Gene Expression
- Genes, APC
- Humans
- Mutation
- Neoplasms
- Trans-Activators
- beta Catenin