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Article

Aberrant P-cadherin expression is an early event in hyperplastic and dysplastic transformation in the colon.

Gut - 1 Apr 2002

Hardy R G, Tselepis C, Hoyland J, Wallis Y, Pretlow T P, Talbot I, Sanders D S A, Matthews G, Morton D, Jankowski J A Z

Abstract excerpt

BACKGROUND: Colorectal adenomatous and, probably, hyperplastic polyp development requires epithelial remodelling and stratification, with loss of E-cadherin expression implicated in adenoma formation. We have shown that P-cadherin, normally expressed in stratified epithelia and placenta, is aberrantly expressed in disturbed epithelial architecture associated with colitis. AIMS: (i) To investigate the role of...

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Identifiers

PMID: 11889072
DOI: 10.1136/gut.50.4.513
PMCID: PMC1773182

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APC

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Source receipt: pubmed, retrieved 7 Sept 2026.

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