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Article

In vivo translational efficiency of different hepatitis C virus 5'-UTRs.

FEBS letters - 14 Jul 1997

Buratti E, Gerotto M, Pontisso P, Alberti A, Tisminetzky S G, Baralle F E

Abstract excerpt

Initiation of translation in hepatitis C virus (HCV) is dependent on the presence of an internal ribosome entry site (IRES) contained in its 341-nt-long 5'-untranslated region (UTR). This region is very conserved among different isolates and has been used to classify HCV isolates in six different genotypes. These genotypes differ in nucleotide sequence that generally preserve the IRES structure. However, the...

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PMID: 9271220
DOI: 10.1016/s0014-5793(97)00715-1

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