Translation efficiencies of the 5' untranslated region from representatives of the six major genotypes of hepatitis C virus using a novel bicistronic reporter assay system.

doi:10.1099/0022-1317-79-10-2359

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Article

Translation efficiencies of the 5' untranslated region from representatives of the six major genotypes of hepatitis C virus using a novel bicistronic reporter assay system.

The Journal of general virology - 1 Oct 1998

Collier A J, Tang S, Elliott R M

Abstract excerpt

The 5' untranslated region (5'UTR) of hepatitis C virus (HCV) contains an internal ribosome entry site (IRES) which directs translation of the viral open reading frame (ORF). The 5'UTR is highly conserved between virus isolates in both primary sequence and predicted secondary structure. We cloned...

Topics

5' Untranslated Regions
Base Sequence
Cells, Cultured
Genotype
Hepacivirus
Molecular Sequence Data
Open Reading Frames
Protein Biosynthesis

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