Article
Translation efficiencies of the 5' untranslated region from representatives of the six major genotypes of hepatitis C virus using a novel bicistronic reporter assay system.
The Journal of general virology - 1 Oct 1998
Collier A J, Tang S, Elliott R M
Abstract excerpt
The 5' untranslated region (5'UTR) of hepatitis C virus (HCV) contains an internal ribosome entry site (IRES) which directs translation of the viral open reading frame (ORF). The 5'UTR is highly conserved between virus isolates in both primary sequence and predicted secondary structure. We cloned and sequenced the 5' regions (nt 18 of the 5'UTR to nt 15 of the core coding sequence) of HCV isolates representing...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.