Article
Differential distribution and internal translation efficiency of hepatitis C virus quasispecies present in dendritic and liver cells.
Blood - 1 Jan 2003
Laporte Julien, Bain Christine, Maurel Patrick, Inchauspe Genevieve, Agut Henri, Cahour Annie
Abstract excerpt
Hepatitis C virus (HCV) is predominantly a hepatotropic virus. Nonetheless, there is mounting evidence that hematopoietic cells may support HCV replication. The HCV 5' untranslated region (5'UTR), responsible for initiation of viral translation, via an internal ribosome entry site (IRES), has been previously described to contain specific nucleotide substitutions when cultured in infected lymphoid cells. Our...
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