Article
Involvement of the 5' proximal coding sequences of hepatitis C virus with internal initiation of viral translation.
Biochemical and biophysical research communications - 18 Nov 1998
Hwang L H, Hsieh C L, Yen A, Chung Y L, Chen D S
Abstract excerpt
The 5' nontranslated region (NTR) of hepatitis C virus (HCV) consists of 341 nucleotides (nt). This region comprises the majority of the internal ribosome entry site (IRES) which controls the efficiency of viral translation. Previous studies of the 3' boundary of the HCV IRES yielded conflicting...
Topics
- 5' Untranslated Regions
- Base Sequence
- Cell Line
- Codon, Initiator
- DNA Primers
- Genes, Reporter
- Hepacivirus
- Humans
- Luciferases
- Models, Molecular
- Molecular Sequence Data
- Mutation