Article
Seven nucleotide changes characteristic of the hepatitis C virus genotype 3 5' untranslated region: correlation with reduced in vitro replication.
The Journal of general virology - 1 Jan 2008
Masante Cyril, Mahias Kathleen, Lourenço Sofia, Dumas Estelle, Cahour Annie, Trimoulet Pascale, Fleury Hervé, Astier-Gin Thérèse, Ventura Michel
Abstract excerpt
Computer analysis of 158 hepatitis C virus (HCV) 5' untranslated region (5' UTR) sequences from the six genotypes showed that the 5' UTR from genotype 3 displays seven specific non-contiguous nucleotide changes, at positions 8, 13, 14, 70, 97, 203 and 224. The purpose of this study was to investigate the impact of these changes on translation and replication activities. Indeed, these modifications could alter...
Topics
- 5' Untranslated Regions
- Base Sequence
- Genotype
- Hepacivirus
- Models, Molecular
- Molecular Sequence Data
- Mutation
- RNA, Viral
- Templates, Genetic
- Transcription, Genetic