Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Analysis of natural variants of the hepatitis C virus internal ribosome entry site reveals that primary sequence plays a key role in cap-independent translation.

Nucleic acids research - 1 Feb 2009

Barría María Inés, González Angel, Vera-Otarola Jorge, León Ursula, Vollrath Valeska, Marsac Delphine, Monasterio Octavio, Pérez-Acle Tomás, Soza Alejandro, López-Lastra Marcelo

Abstract excerpt

The HCV internal ribosome entry site (IRES) spans a region of approximately 340 nt that encompasses most of the 5' untranslated region (5'UTR) of the viral mRNA and the first 24-40 nt of the core-coding region. To investigate the implication of altering the primary sequence of the 5'UTR on IRES activity, naturally occurring variants of the 5'UTR were isolated from clinical samples and analyzed. The impact of the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to 5' Untranslated Regions
Share to Circular Dichroism

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Hepacivirus

Share to Hepatitis C, Chronic

Share to Peptide Chain Initiation, Translational

Share to Regulatory Sequences, Ribonucleic Acid

Share to RNA Caps

Share to RNA, Viral

Source

Open in PubMed Open full text

Identifiers

PMID: 19106142
DOI: 10.1093/nar/gkn1022
PMCID: PMC2647302

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Analysis of natural variants of the hepatitis C virus internal ribosome entry site reveals that primary sequence plays a key role in cap-independent translation.PMID 19106142Read ↗

Understanding the potential of hepatitis C virus internal ribosome entry site domains to modulate translation initiation via their structure and functionSemantic proximity Read ↗

A potential RNA drug target in the hepatitis C virus internal ribosomal entry site.Semantic proximity Read ↗

HCVIVdb: The hepatitis-C IRES variation database.Semantic proximity Read ↗

Mutational analysis of the different bulge regions of hepatitis C virus domain II and their influence on internal ribosome entry site translational ability.Semantic proximity Read ↗

Stability of a stem-loop involving the initiator AUG controls the efficiency of internal initiation of translation on hepatitis C virus RNA.Semantic proximity Read ↗

A Phylogenetically Conserved Stem-Loop Structure at the 5′ Border of the Internal Ribosome Entry Site of Hepatitis C Virus Is Required for Cap-Independent Viral TranslationSemantic proximity Read ↗

The hepatitis C virus internal ribosome-entry site: a new target for antiviral researchSemantic proximity Read ↗

Translation of human hepatitis C virus RNA in cultured cells is mediated by an internal ribosome-binding mechanismSemantic proximity Read ↗

The hepatitis C virus internal ribosome entry site adopts an ion-dependent tertiary fold.Semantic proximity Read ↗

Crystal structure of an RNA tertiary domain essential to HCV IRES-mediated translation initiationSemantic proximity Read ↗

Hepatitis C Virus Translation RegulationSemantic proximity Read ↗

Lack of clinical significance of variability in the internal ribosome entry site of hepatitis C virus.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.