Article
Overexpression of transforming growth factor beta type I receptor abolishes malignant phenotype of a rat bladder carcinoma cell line.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research - 1 Aug 1997
Okamoto M, Oyasu R
Abstract excerpt
Transforming growth factor beta1 (TGF-beta1), a potent growth inhibitor of bladder carcinoma cells, elicits its effects by binding to cell surface receptors. LMC19, a highly invasive and metastatic rat bladder carcinoma cell line, was insensitive to the growth-suppressive effect of TGF-beta1, and...
Topics
- Activin Receptors, Type I
- Animals
- Carcinoma
- Cell Division
- Gene Expression
- Humans
- Mice
- Mice, Nude
- Neoplasms, Experimental
- Phenotype
- Protein Serine-Threonine Kinases
- RNA, Messenger
- RNA, Neoplasm
- Rats
- Receptor, Transforming Growth Factor-beta Type I
- Receptors, Transforming Growth Factor beta
- Transfection
- Transforming Growth Factor beta