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Article

Mutation of TGF-β receptor II facilitates human bladder cancer progression through altered TGF-β1 signaling pathway.

International journal of oncology - 1 Nov 2013

Bian Jing, Li Bo, Zeng Xiaoyong, Hu Heyu, Hong Yi, Ouyang Hui, Zhang Xiaoxue, Wang Zhihua, Zhu Huifen, Lei Ping, Huang Bo, Shen Guanxin

Abstract excerpt

Tumor cells commonly adapt survival strategies by downregulation or mutational inactivation of TGF-β receptors thereby reversing TGF-β1-mediated growth arrest. However, TGF-β1-triggered signaling also has a protumor effect through promotion of tumor cell migration. The mechanism(s) through which malignant cells reconcile this conflict by avoiding growth arrest, but strengthening migration remains largely unclear....

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Source

Identifiers

PMID: 23970096
DOI: 10.3892/ijo.2013.2065

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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