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Article

Cellular growth inhibition by IGFBP‐3 and TGF‐β <sub>1</sub> requires LRP‐1

1 Nov 2003

Abstract excerpt

The type V TGF-beta receptor (TbetaR-V)/IGFBP-3 receptor mediates the IGF-independent growth inhibition induced by IGFBP-3. It also mediates the growth inhibitory response to TGF-beta1 in concert with other TGF-beta receptor types, and its loss may contribute to the malignant phenotype of human carcinoma cells. Here we demonstrate that TbetaR-V is identical to LRP-1/alpha2M receptor as shown by MALDI-TOF analysis...

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Share to Growth Hormone and Insulin-like Growth Factors
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Identifiers

PMID: 14597676
DOI: 10.1096/fj.03-0256com

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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