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Article

Transfection of the type I TGF-beta receptor restores TGF-beta responsiveness in pancreatic cancer.

International journal of cancer - 5 Oct 1998

Wagner M, Kleeff J, Lopez M E, Bockman I, Massaqué J, Korc M

Abstract excerpt

Transforming growth factor-beta (TGF-beta) signaling is initiated following heterodimerization of the type II TGF-beta receptor (TbetaRII) with the type I TGF-beta receptor (TbetaRI). Both receptors are required for TGF-beta responsiveness. In the present study, we characterized the actions of TGF-beta1 in T3M4 human pancreatic cancer cells, which express low levels of TbetaRI and high levels of TbetaRII. Cells...

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Source

Identifiers

PMID: 9754660
DOI: 10.1002/(sici)1097-0215(19981005)78:2<255::aid-ijc21>3.0.co;2-8

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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