Article
The amino-terminal region of SV40 large T antigen is sufficient to induce hepatic tumours in mice.
Oncogene - 10 Sept 1998
Bennoun M, Grimber G, Couton D, Seye A, Molina T, Briand P, Joulin V
Abstract excerpt
The transforming activity of SV40 large T-antigen (Tag) depends on its binding to cellular proteins involved in the control of the cell cycle (p53, pRb, p300..) and on the J-domain region in the amino-terminus. We established transgenic lines expressing wild-type or Tag mutant proteins lacking on...
Topics
- Animals
- Antigens, Polyomavirus Transforming
- Antithrombin III
- Binding Sites
- Carcinoma, Hepatocellular
- Liver Neoplasms, Experimental
- Mice
- Mice, Transgenic
- Mutation
- Phenotype
- Promoter Regions, Genetic
- Retinoblastoma Protein
- Tumor Suppressor Protein p53