Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The amino-terminal region of SV40 large T antigen is sufficient to induce hepatic tumours in mice.

Oncogene - 10 Sept 1998

Bennoun M, Grimber G, Couton D, Seye A, Molina T, Briand P, Joulin V

Abstract excerpt

The transforming activity of SV40 large T-antigen (Tag) depends on its binding to cellular proteins involved in the control of the cell cycle (p53, pRb, p300..) and on the J-domain region in the amino-terminus. We established transgenic lines expressing wild-type or Tag mutant proteins lacking one of the three transforming domains, to determine the respective contributions of these domains to hepatic tumour...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Binding Sites
Share to Carcinoma, Hepatocellular
Share to Mice

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Mice, Transgenic

Share to Mutation

Share to Phenotype

Share to Promoter Regions, Genetic

Share to Tumor Suppressor Protein p53

Source

Identifiers

PMID: 9771968
DOI: 10.1038/sj.onc.1202047

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The amino-terminal region of SV40 large T antigen is sufficient to induce hepatic tumours in mice.PMID 9771968Read ↗

SV40 large T antigen targets multiple cellular pathways to elicit cellular transformation.Semantic proximity Read ↗

Dissociation of Rb-binding and anchorage-independent growth from immortalization and tumorigenicity using SV40 mutants producing N-terminally truncated large T antigens.Semantic proximity Read ↗

The block of adipocyte differentiation by a C-terminally truncated, but not by full-length, simian virus 40 large tumor antigen is dependent on an intact retinoblastoma susceptibility protein family binding domain.Semantic proximity Read ↗

Reduced p53 dosage associated with mammary tumor metastases in C3(1)/TAG transgenic mice.Semantic proximity Read ↗

Induction of genomic instability in SV40 transformed human cells: sufficiency of the N-terminal 147 amino acids of large T antigen and role of pRB and p53.Semantic proximity Read ↗

Simian Virus 40 T-Antigen-Mediated Gene Regulation in Enterocytes Is Controlled Primarily by the Rb-E2F PathwaySemantic proximity Read ↗

Transgenic mouse models of hepatitis B virus‐associated hepatocellular carcinomaSemantic proximity Read ↗

Conditional liver-specific expression of simian virus 40 T antigen leads to regulatable development of hepatic neoplasm in transgenic mice.Semantic proximity Read ↗

Expression of wild-type and mutant simian virus 40 large tumor antigens in villus-associated enterocytes of transgenic mice.Semantic proximity Read ↗

Inactivation of pRB-Related Proteins p130 and p107 Mediated by the J Domain of Simian Virus 40 Large T AntigenSemantic proximity Read ↗

Role of pRb-related proteins in simian virus 40 large-T-antigen-mediated transformation.Semantic proximity Read ↗

Independent expression of the transforming amino-terminal domain of SV40 large I antigen from an alternatively spliced third SV40 early mRNA.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.