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Article

Temperature sensitivity of a class I tRNA synthetase induced by artificial breakage of polypeptide chain.

Molecules and cells - 30 Jun 1997

Kim S J, Kim S

Abstract excerpt

Escherichia coli methionyl-tRNA synthetase consists of catalytic, anticodon-binding, and dimerization domains. The polypeptide was genetically cleaved and expressed as multiple subunits to investigate how peptide breakage affects the activity and stability of the enzyme. Mutants cleaved near conserved or functionally important sites were inactive. A few bipartite mutants were active, but they showed temperature...

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PMID: 9264027

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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