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Article

Site-specific incorporation of ε-N-crotonyllysine into histones.

Angewandte Chemie (International ed. in English) - 16 Jul 2012

Kim Chan Hyuk, Kang Mingchao, Kim Hak Joong, Chatterjee Abhishek, Schultz Peter G

Abstract excerpt

A novel post-translationally modified amino acid, crotonyllysine (Kcr), was genetically incorporated into proteins in bacterial and mammalian cells using an evolved pyrrolysyl-tRNA/synthetase-tRNA pair. The ability to produce histones with homogenous, site-specific Kcr modifications will be valua...

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Identifiers

PMID: 22689270
DOI: 10.1002/anie.201203349
PMCID: PMC3783207

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22689270-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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