Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A method to site-specifically introduce methyllysine into proteins in E. coli.

Chemical communications (Cambridge, England) - 14 Aug 2010

Ai Hui-Wang, Lee Jae Wook, Schultz Peter G

Abstract excerpt

A mutant pyrrolysyl-tRNA synthetase/tRNA pair was used to genetically encode allylcarbamoyl methyllysine in bacteria. This amino acid can be converted to methyllysine with a ruthenium catalyst, providing a straightforward approach for site-specifically introducing methyllysine residues into proteins.

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acyl-tRNA Synthetases
Share to Escherichia coli
Share to Escherichia coli Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Lysine

Share to Mutation

Share to RNA, Transfer

Source

Open in PubMed Open full text

Identifiers

PMID: 20571694
DOI: 10.1039/c0cc00108b
PMCID: PMC2928331

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A method to site-specifically introduce methyllysine into proteins in E. coli.PMID 20571694Read ↗

Site-specific incorporation of ε-N-crotonyllysine into histones.Semantic proximity Read ↗

Thiol-yne radical reaction mediated site-specific protein labeling via genetic incorporation of an alkynyl-L-lysine analogue.Semantic proximity Read ↗

Expanding the genetic code.Semantic proximity Read ↗

Genetic incorporation of twelve meta-substituted phenylalanine derivatives using a single pyrrolysyl-tRNA synthetase mutant.Semantic proximity Read ↗

Genetic Code Expansion Tools to Study Lysine AcylationSemantic proximity Read ↗

Genetic incorporation of unnatural amino acids into proteins in Mycobacterium tuberculosis.Semantic proximity Read ↗

Stereochemical basis for engineered pyrrolysyl-tRNA synthetase and the efficient in vivo incorporation of structurally divergent non-native amino acids.Semantic proximity Read ↗

The genetic incorporation of p-azidomethyl-l-phenylalanine into proteins in yeast.Semantic proximity Read ↗

Thermophilic Pyrrolysyl-tRNA Synthetase Mutants for Enhanced Mammalian Genetic Code Expansion.Semantic proximity Read ↗

Site-specific incorporation of a fluorescent terphenyl unnatural amino acid.Semantic proximity Read ↗

A Designed, Highly Efficient Pyrrolysyl-tRNA Synthetase Mutant Binds o-Chlorophenylalanine Using Two Halogen Bonds.Semantic proximity Read ↗

In vivo incorporation of an alkyne into proteins in Escherichia coli.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.