Article
Expression and mutation of the tumor suppressor gene p53 in AIDS-associated Kaposi's sarcoma.
The American Journal of dermatopathology - 1 Aug 1997
Li J J, Huang Y Q, Cockerell C J, Zhang W G, Nicolaides A, Friedman-Kien A E
Abstract excerpt
Alteration of the p53 gene is the most frequent event reported in human cancer, and p53 mutations have been observed in various neoplasms, including certain forms of skin cancer. Therefore, we postulated that p53 may also be involved in Kaposi's sarcoma associated with AIDS (AIDS-KS). Expression of the p53 gene was examined in freshly isolated tumor biopsy specimens from 15 patients with AIDS-KS. p53 mRNA was...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.