Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Molecular abnormalities of mdm2 and p53 genes in adult soft tissue sarcomas.

Cancer research - 1 Feb 1994

Cordon-Cardo C, Latres E, Drobnjak M, Oliva M R, Pollack D, Woodruff J M, Marechal V, Chen J, Brennan M F, Levine A J

Abstract excerpt

Genetic alterations in the p53 and mdm2 genes have been reported to occur in soft tissue sarcomas. This study was designed to determine the prevalence and potential clinical value of detected molecular abnormalities and altered patterns of expression of mdm2 and p53 genes in adult soft tissue sarcomas. A cohort of 211 soft tissue sarcomas from adults that were both clinically and pathologically well characterized...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DNA, Neoplasm
Share to Gene Deletion
Share to Gene Expression

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genes, p53

Share to Genotype

Share to Immunohistochemistry

Share to Phenotype

Share to Point Mutation

Source

Identifiers

PMID: 8306343

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Molecular abnormalities of mdm2 and p53 genes in adult soft tissue sarcomas.PMID 8306343Read ↗

Molecular and immunohistochemical identification of p53 alterations in bone and soft tissue sarcomas.Semantic proximity Read ↗

MDM2 Gene Amplification and Transcript Levels in Human Sarcomas: Relationship to TP53 Gene StatusSemantic proximity Read ↗

Amplification of the MDM2 gene, but not expression of splice variants of MDM2 MRNA, is associated with prognosis in soft tissue sarcoma.Semantic proximity Read ↗

MDM2 Amplified Sarcomas: A Literature ReviewSemantic proximity Read ↗

Prognostic implications of p53 nuclear overexpression and high proliferation index of Ki-67 in adult soft-tissue sarcomas.Semantic proximity Read ↗

Soft Tissue Sarcomas with Chromosomal Alterations in the 12q13-15 Region: Differential Diagnosis and Therapeutic ImplicationsSemantic proximity Read ↗

Analysis of p53 and mdm2 proteins in malignant fibrous histiocytoma in absence of gene alteration: prognostic significance.Semantic proximity Read ↗

MDM2 inhibitors in sarcomas: results and next stepsSemantic proximity Read ↗

The MDM2 gene amplification databaseSemantic proximity Read ↗

The Role of MDM2 Amplification and Overexpression in Tumorigenesis.Semantic proximity Read ↗

Impact of supraphysiologic MDM2 expression on chromatin networks and therapeutic responses in sarcomaSemantic proximity Read ↗

Infrequency of MDM2 gene amplification in pediatric solid tumors and lack of association with p53 mutations in adult squamous cell carcinomas.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.