Molecular abnormalities of mdm2 and p53 genes in adult soft tissue sarcomas.

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Article

Molecular abnormalities of mdm2 and p53 genes in adult soft tissue sarcomas.

Cancer research - 1 Feb 1994

Cordon-Cardo C, Latres E, Drobnjak M, Oliva M R, Pollack D, Woodruff J M, Marechal V, Chen J, Brennan M F, Levine A J

Abstract excerpt

Genetic alterations in the p53 and mdm2 genes have been reported to occur in soft tissue sarcomas. This study was designed to determine the prevalence and potential clinical value of detected molecular abnormalities and altered patterns of expression of mdm2 and p53 genes in adult soft tissue sar...

Topics

Adult
Analysis of Variance
Cell Nucleus
Cohort Studies
DNA, Neoplasm
Gene Amplification
Gene Deletion
Gene Expression
Genes, p53
Genotype
Humans
Immunohistochemistry
Neoplasm Proteins
Nuclear Proteins
Phenotype
Point Mutation
Proto-Oncogene Proteins
Proto-Oncogene Proteins c-mdm2

Source

Open in PubMed

Identifiers

PMID: 8306343

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8306343-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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