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Article

Ultraviolet-induced p53 mutations in atypical fibroxanthoma.

The American journal of pathology - 1 Jul 1994

Dei Tos A P, Maestro R, Doglioni C, Gasparotto D, Boiocchi M, Laurino L, Fletcher C D

Abstract excerpt

Atypical fibroxanthoma (AFX) is an uncommon neoplasm of the superficial soft tissue occurring in actinically damaged skin of elderly patients. Sun-exposed skin also represents the main site of squamous and basal cell carcinomas and malignant melanoma, and a key role for ultraviolet (UV) radiation in their pathogenesis has long been suspected. UV-related mutations of the p53 gene have been identified in human skin...

Topics

Base Sequence
Genes, p53
Histiocytoma, Benign Fibrous
Humans
Molecular Sequence Data
Mutation
Skin Neoplasms
Ultraviolet Rays

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 8030743
PMCID: PMC1887293

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-8030743-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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