Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Molecular basis of HNPCC: mutations of MMR genes.

Human mutation - 1 Jan 1997

Papadopoulos N, Lindblom A

Abstract excerpt

Hereditary nonpolyposis colorectal cancer (HNPCC) is inherited as a dominant disorder caused by germline defects in one of at least four mismatch repair (MMR) genes. Two of these genes, hMSH2 and hMLH1, account for the vast majority of the germline mutations in HNPCC kindreds, whereas hPMS1 and h...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenosine Triphosphatases
Share to Carrier Proteins
Share to DNA-Binding Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Repair

Share to Mutation

Share to Neoplasm Proteins

Share to Nuclear Proteins

Source

Identifiers

PMID: 9259192
DOI: 10.1002/(SICI)1098-1004(1997)10:2<89::AID-HUMU1>3.0.CO;2-H

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-9259192-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Molecular basis of HNPCC: mutations of MMR genes.PMID 9259192Read ↗

The genetics of HNPCC: application to diagnosis and screening.Semantic proximity Read ↗

Hereditary nonpolyposis colorectal cancer: the syndrome, the genes, and historical perspectives.Semantic proximity Read ↗

Analysis of mismatch repair gene mutations in Turkish HNPCC patients.Semantic proximity Read ↗

Molecular genetics of hereditary non-polyposis colorectal cancer (HNPCC).Semantic proximity Read ↗

hMSH2 is the most commonly mutated MMR gene in a cohort of Greek HNPCC patients.Semantic proximity Read ↗

Differential features of colorectal cancers fulfilling Amsterdam criteria without involvement of the mutator pathway.Semantic proximity Read ↗

DNA mismatch repair gene mutations in human cancer.Semantic proximity Read ↗

Mismatch Repair and the Hereditary Non-polyposis Colorectal Cancer Syndrome (HNPCC)Semantic proximity Read ↗

Spectrum and frequencies of mutations inMSH2 andMLH1 identified in 1,721 German families suspected of hereditary nonpolyposis colorectal cancerSemantic proximity Read ↗

Malignant melanoma in patients with hereditary nonpolyposis colorectal cancer.Semantic proximity Read ↗

The hereditary nonpolyposis colorectal cancer syndrome: genetics and clinical implications.Semantic proximity Read ↗

hMLH1 mutations in hereditary nonpolyposis colorectal cancer kindreds. Mutations in brief no. 182. Online.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.