Article
Analysis of mismatch repair gene mutations in Turkish HNPCC patients.
Familial cancer - 1 Sept 2010
Tunca Berrin, Pedroni Monica, Cecener Gulsah, Egeli Unal, Borsi Enrica, Zorluoglu Abdullah, Di Gregorio Carmela, Yilmazlar Tuncay, Yerci Omer, de Leon Maurizio Ponz
Abstract excerpt
Hereditary non-polyposis colorectal cancer (HNPCC or Lynch syndrome) is caused by the inheritance of a mutant allele of a DNA mismatch repair gene. We aimed to investigate types and frequencies of mismatch repair (MMR) gene mutations in Turkish patients with HNPCC and to identify specific biomarkers for early diagnosis of their non-symptomatic kindred's. The molecular characteristics of 28 Turkish colorectal...
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