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Article

Transcription enhances intrachromosomal homologous recombination in mammalian cells.

Molecular and cellular biology - 1 Dec 1992

Nickoloff J A

Abstract excerpt

The influence of transcription on homologous intrachromosomal recombination between direct and inverted repeats has been examined by using Chinese hamster ovary cells. Recombination was monitored between two integrated neomycin (neo) genes, including one silent allele and a second allele regulated by the inducible mouse mammary tumor virus promoter. Transcription of mouse mammary tumor virus neo alleles was...

Topics

Alleles
Animals
Blotting, Southern
CHO Cells
Cricetinae
Dexamethasone
Gene Conversion
Gene Expression Regulation
Kinetics
Mammary Tumor Virus, Mouse
Multigene Family
Neomycin

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Promoter Regions, Genetic

Recombination, Genetic

Transcription, Genetic

Source

Open in PubMed Open full text

Identifiers

PMID: 1333040
DOI: 10.1128/mcb.12.12.5311-5318.1992
PMCID: PMC360468

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1333040-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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