Increase of spontaneous intrachromosomal homologous recombination in mammalian cells expressing a mutant p53 protein.

doi:10.1038/sj.onc.1200931

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Article

Increase of spontaneous intrachromosomal homologous recombination in mammalian cells expressing a mutant p53 protein.

Oncogene - 6 Mar 1997

Bertrand P, Rouillard D, Boulet A, Levalois C, Soussi T, Lopez B S

Abstract excerpt

Homologous recombination plays an essential role in processes involved in genome stability/instability, such as molecular evolution, gene diversification, meiotic chromosome segregation, DNA repair and chromosomal rearrangements. p53 devoid cells exhibit predisposition to neoplasia, defects in G1...

Topics

Animals
Cell Line
Cloning, Molecular
Gamma Rays
Gene Conversion
Gene Deletion
Mice
Mutation
Recombination, Genetic
Tumor Suppressor Protein p53

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