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Article

LRP‐1/TβR‐V mediates TGF‐β1‐induced growth inhibition in CHO cells

27 Feb 2004

Abstract excerpt

The type V transforming growth factor-beta (TGF-beta) receptor (TbetaR-V) is hypothesized to be involved in cellular growth inhibition by TGF-beta(1). Recently, TbetaR-V was found to be identical to low density lipoprotein receptor-related protein-1 (LRP-1). Here we demonstrate that TGF-beta(1) inhibits growth of wild-type CHO cells but not LRP-1-deficient mutant cells (CHO-LRP-1(-) cells). Stable transfection of...

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Identifiers

PMID: 15044004
DOI: 10.1016/s0014-5793(04)00185-1

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